Selected Publications

From Leonardo Morsut’s previous research experiences:

  • Morsut L*, Roybal KT*, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering customized cell sensing and response behaviors using synthetic Notch receptors. Cell. 2016 Feb 11;164(4):780-91. PMID: 26830878. [PubMed] (*co-first authors with equal contributions) FEATURED IN: Cell, Nature Biotechnology, Nature Methods, Nature Medicine’s Notable Advances 2016, Forbes’ “Pushing the T-cell engineering frontier”
  • (PATENT) Lim W, Morsut L, Roybal K. Binding-triggered transcriptional switches and methods of use thereof. US 9670281 B2. University of California, San Francisco, Apr 12, 2016. https://patents.google.com/patent/US9670281B2/en
  • Dupont S*, Morsut L*, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N, Piccolo S. Role of YAP/TAZ in mechanotransduction. Nature. 2011 Jun 9;474(7350):179-183. PMID: 21654799. [PubMed] (*co-first authors)
  • Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S. Negative control of Smad activity by Ectodermin/Tif1γ patterns the mammalian embryo. Development. 2010 August 1;137(15):2571-8. PMID: 20573697. [PubMed]

From USC:

  • Morsut L. Programming cells to build tissues with synthetic biology: a new pathway towards engineering development and regeneration. In: Gardiner, DM, ed. Regenerative Engineering and Developmental Biology: Principles and Applications. Boca Raton, FL: CRC Press; 2017. (This invited book chapter describes our philosophy of tissues as complex systems made of simpler parts—cells—that interact with each other via signaling pathways, and that also are the mechanical component of the tissue itself.)
  • Johnson MB, March AR, Morsut L. Engineering multicellular systems: using synthetic biology to control tissue self-organization. Current opinion in biomedical engineering. 2017 Dec;4 doi: 10.1016/j.cobme.2017.10.008. PMID: 29308442. [Pubmed] (This invited review describes recent work and the potential next generation implementation of synthetic biology tools for regenerative medicine.)