University of Southern California

Morsut Lab

USC Stem Cell

A synthetic biology approach to tissue engineering

Multicellular biological systems build tissues by means of development, starting from simpler forms to generate complex structural and functional tissues. Tissue engineers trying to recapitulate these events are limited in their efforts, because they are using the cells’ own receptor and information processing systems. To generate tissue with user-defined structure, and to increase the controls available for tissue engineering, we use genetic engineering to design tissues with cellular precision from the bottom-up. In order to maximize performance, we interface with existing approaches to make tissues (tissue engineering, organoids, etc.).